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Eur J Endocrinol. 2015 Jun 3. pii: EJE-15-0284. [Epub ahead of print]

Coronary Artery Disease Risk among Obese Metabolically Healthy Young Men.

Twig G1, Gerstein H2, Ben-Ami Shor D3, Derazne E4, Tzur D5, Afek A6, Tirosh A7.

Abstract

OBJECTIVE:

The aim of this study was to assess CAD risk among obese young men without metabolic risk factors.

DESIGN:

longitudinal study in a historical cohort Methods: Incident CAD during a median follow-up of 6.1 years was assessed among 31,684 young men (mean age 31.2±5.7 years) of the Metabolic, Lifestyle and Nutrition Assessment in Young Adults (MELANY) cohort. Participants were categorized by BMI and the number of metabolic abnormalities (based on the Adult Treatment Panel-III). Metabolically healthy (MH) obesity was defined as BMI≥30 kg/m2 in the presence of normal blood pressure and normal levels of fasting glucose, triglyceride and HDL-cholesterol levels (n=599; 1.9%). Cox proportional hazard models were applied.

RESULTS:

There were 198 new cases of CAD that were diagnosed during 209,971 person-years of follow-up, of which 6 cases occurred among MH obese. The incidence of CAD among MH lean, overweight and obese participates was 0.23, 0.45 and 1.0 per 1,000 person-years, respectively. In a multivariable model adjusted for clinical and biochemical CAD risk factors, a higher CAD risk was observed among MH-obese (HR=3.08; 95%CI=1.10-8.68, p=0.033), compared to MH-normal weight subjects. This risk persisted when BMI was treated as a time-dependent variable, or when fasting glucose, HDL-cholesterol, triglycerides or blood pressure were added to the model. Similar results were also obtained when a more permissive definition of metabolic health was used.

CONCLUSIONS:

Obesity may continue to contribute to increased risk for incident CAD in young men even in the presence of a healthy metabolic profile.

PMID: 26041076 [PubMed – as supplied by publisher]

via Coronary Artery Disease Risk among Obese Metabolically Healthy Young Men. – PubMed – NCBI.