Current Osteoporosis Reports, 10/31/2013 Review Article Clinical Article
- In most cases, Z scores rather than T scores should be used to define “low BMD” in premenopausal women.
- The finding of low BMD in a premenopausal woman should prompt thorough evaluation for secondary causes of bone loss.
- If a secondary cause is found, management should focus on treatment of this condition.
- In a few cases where the secondary cause cannot be eliminated, treatment with a bone active agent to prevent bone loss should be considered.
- In women with no fractures and no known secondary cause, low BMD is associated with microarchitectural defects similar to young women with fractures; however, no longitudinal data are available to allow use of BMD to predict fracture risk.
- BMD is likely to be stable in these women with isolated low BMD, and pharmacologic therapy is rarely necessary.