CTCA initiates New Clinical Study of Immunotherapy Combined With Chemotherapy Colon Cancer News Today

Cancer Treatment Centers of America (CTCA) recently announced it will begin a Phase Ib/II clinical trial using a novel immunotherapy for the treatment of patients with advanced kidney, pancreatic, colorectal carcinoma and non-small cell lung cancer.

The “NivoPlus” study combines nivolumab (an immunotherapy drug) with the FDA-approved irinotecan, temsirolimus, and a combination of capecitabine and irinotecan (all chemotherapy drugs).

The combination of chemotherapeutic agents with nivolumab intends to stimulate the patient’s immune system to improve the results that would not be achieved using chemotherapy alone. This is the first time that this combination of immunotherapy and chemotherapy is being investigated and is the third combination study launched since last year by CTCA at the Western Regional Medical Center (Western) in Goodyear, Arizona

The company aims to enroll 49 patients on the multi-arm NivoPlus clinical trial, and has already announced the first patient already received treatment.

“Some of these drug combinations are not available elsewhere, giving CTCA patients additional treatment options,” said in a recent news release Dr. Glen Weiss, Director of Clinical Research and Medical Oncologist, CTCA at Western. “Our ultimate goal is to evaluate if these combinations yield improved results for our patients.”

Nivolumab inhibits the PD-1 protein, which otherwise blocks the body’s immune system from attacking tumor cells.

via CTCA initiates New Clinical Study of Immunotherapy Combined With Chemotherapy Colon Cancer News Today.

Enzyme that triggers muscle wasting could be key to REVERSING signs of ageing

The effects can be devastating for patients who can develop features such as muscle wasting and weakness, weight gain, thinning of the bones, diabetes, high blood pressure and heart disease.

Dr Hassan-Smith said: ‘Looking at this particular enzyme seemed like an intriguing way forward.

‘We knew how it works in relation to Cushing’s Syndrome, which is characterised by similar symptoms, and thought it would be worthwhile applying what we knew to the ageing population.’

via Enzyme that triggers muscle wasting could be key to REVERSING signs of ageing | Daily Mail Online | CushieBlog.

Coronary Artery Disease Risk among Obese Metabolically Healthy Young Men.

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Eur J Endocrinol. 2015 Jun 3. pii: EJE-15-0284. [Epub ahead of print]

Coronary Artery Disease Risk among Obese Metabolically Healthy Young Men.

Twig G1, Gerstein H2, Ben-Ami Shor D3, Derazne E4, Tzur D5, Afek A6, Tirosh A7.

Abstract

OBJECTIVE:

The aim of this study was to assess CAD risk among obese young men without metabolic risk factors.

DESIGN:

longitudinal study in a historical cohort Methods: Incident CAD during a median follow-up of 6.1 years was assessed among 31,684 young men (mean age 31.2±5.7 years) of the Metabolic, Lifestyle and Nutrition Assessment in Young Adults (MELANY) cohort. Participants were categorized by BMI and the number of metabolic abnormalities (based on the Adult Treatment Panel-III). Metabolically healthy (MH) obesity was defined as BMI≥30 kg/m2 in the presence of normal blood pressure and normal levels of fasting glucose, triglyceride and HDL-cholesterol levels (n=599; 1.9%). Cox proportional hazard models were applied.

RESULTS:

There were 198 new cases of CAD that were diagnosed during 209,971 person-years of follow-up, of which 6 cases occurred among MH obese. The incidence of CAD among MH lean, overweight and obese participates was 0.23, 0.45 and 1.0 per 1,000 person-years, respectively. In a multivariable model adjusted for clinical and biochemical CAD risk factors, a higher CAD risk was observed among MH-obese (HR=3.08; 95%CI=1.10-8.68, p=0.033), compared to MH-normal weight subjects. This risk persisted when BMI was treated as a time-dependent variable, or when fasting glucose, HDL-cholesterol, triglycerides or blood pressure were added to the model. Similar results were also obtained when a more permissive definition of metabolic health was used.

CONCLUSIONS:

Obesity may continue to contribute to increased risk for incident CAD in young men even in the presence of a healthy metabolic profile.

PMID: 26041076 [PubMed – as supplied by publisher]

via Coronary Artery Disease Risk among Obese Metabolically Healthy Young Men. – PubMed – NCBI.

Snow shoveling: How to avoid a heart attack – WTOP

“Shoveling snow can, in fact, precipitate a heart attack, and it does for thousands of Americans every year,” says Dr. Warren Levy, chief medical officer of Virginia Heart, one of the largest cardiology practices in the region.

He says shoveling snow involves a level of exertion that most of us just are not used to and don’t do on a daily basis.

“It is the same sort of trouble people get into [when they] have never exercised and decide to suddenly train for a marathon,” Levy explained.

People most likely to have problems while shoveling snow are those already diagnosed with heart disease, or who have significant risk factors, such as high blood pressure, obesity, diabetes, cigarette smoking, a strong family history or a sedentary lifestyle.

Read more at Snow shoveling: How to avoid a heart attack – WTOP.

How to cook vegetables – Cook Smarts

veggies

This infographic and the videos below teach you our favorite cooking formulas (or techniques) for enjoying a wide variety of vegetables: sauteing, steaming, roasting, boiling, microwaving, including in salads, pureeing into soups, and turning into zucchini noodles. Enjoy them in season for the tastiest (and least expensive results).

Read more at How to cook vegetables – Cook Smarts.

NINDS Know Stroke Campaign – Know Stroke Home

Each year in the United States, there are more than 795,000 strokes. Stroke is the fourth leading cause of death in the country and causes more serious long-term disabilities than any other disease. Nearly three-quarters of all strokes occur in people over the age of 65 and the risk of having a stroke more than doubles each decade after the age of 55.

The National Institutes of Health through the National Institute of Neurological Disorders and Stroke (NINDS) developed the Know Stroke. Know the Signs. Act in Time. campaign to help educate the public about the symptoms of stroke and the importance of getting to the hospital quickly.

Read the entire article at NINDS Know Stroke Campaign – Know Stroke Home.

2014 in review

The WordPress.com stats helper monkeys prepared a 2014 annual report for this blog.

Here’s an excerpt:

A San Francisco cable car holds 60 people. This blog was viewed about 940 times in 2014. If it were a cable car, it would take about 16 trips to carry that many people.

Click here to see the complete report complete with fireworks!